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They possess unique biomedical bioactivities, special physic and chemical properties, including magnetic, electrochemical, thermodynamic and catalytic properties [110,111,112]

In this respect it was shown that linear PEI (22 kDa) was more toxic than branched PEI (25 kDa) and also related to the amount of PEI used in polyplex systems as expressed by the N/P ration (amount of nitrogen in the polymer related to the amount of DNA)

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A close relationship between a defect or down-regulation of microsomal triglyceride transfer protein is associated with the development of MASLD (Peng et al